The University of Ferrara YAP-(S)PET scanner is currently being employed in small animal SPECT studies, with 99 mTc labeled radiotracers, with the goal of obtaining quantitative activity measurements from region of interest (ROI) analysis of reconstructed images of rats. The measurements will be compared directly with traditional ex vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated relative to a standard Isodose dose calibrator which was calibrated with various certified activity sources. The calibration factor K was defined as the ratio of the activity measured with the Isodose (MBq) and the image count rate (cps). We findK = 0 1346 0 0008MBq cps, with good linearity over a wide range of activities (9–88 MBq).With the calibrated scanner we compared results of activity measurements from images of whole-rat heart acquisitions versus excised hearts.We found good agreement between the two measurements.

YAP-(S)PET small animal scanner: Quantitative results

DI DOMENICO, Giovanni;ZAVATTINI, Guido;MORETTI, Elena;PIFFANELLI, Adriano;GIGANTI, Melchiore;MOTTA, Alfonso;SABBA, NICOLA;UCCELLI, Licia;BENINI, ELISA;DUATTI, Adriano;BOLZATI, Cristina;BOSCHI, Alessandra;DEL GUERRA, Alberto
2003

Abstract

The University of Ferrara YAP-(S)PET scanner is currently being employed in small animal SPECT studies, with 99 mTc labeled radiotracers, with the goal of obtaining quantitative activity measurements from region of interest (ROI) analysis of reconstructed images of rats. The measurements will be compared directly with traditional ex vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated relative to a standard Isodose dose calibrator which was calibrated with various certified activity sources. The calibration factor K was defined as the ratio of the activity measured with the Isodose (MBq) and the image count rate (cps). We findK = 0 1346 0 0008MBq cps, with good linearity over a wide range of activities (9–88 MBq).With the calibrated scanner we compared results of activity measurements from images of whole-rat heart acquisitions versus excised hearts.We found good agreement between the two measurements.
DI DOMENICO, Giovanni; Zavattini, Guido; Moretti, Elena; Piffanelli, Adriano; Giganti, Melchiore; Motta, Alfonso; Sabba, Nicola; Uccelli, Licia; Benini, Elisa; Duatti, Adriano; Bolzati, Cristina; Boschi, Alessandra; DEL GUERRA, Alberto
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1200842
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 16
social impact