Continuing our studies on the structure-activity relationships (SAR) of 4-iodo-1-β-D-ribofuranosyl-3-carbomethoxy pyrazole (IPCAR), the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-pyrazole derivs., with the 2'-deoxy-β-D-ribofuranosyl group and finally with the 2', 3'-dideoxy-D-glycero-pentofuranosyl-moiety. None of the new compds. display any interesting antiviral, antitumor, cytotoxicity, and antibacterial activities up to 300 μM.
Pyrazole related nucleosides 5. synthesis and biological activity of 2'-deoxy-2', 3'-dideoxy- and acyclo-analogs of 4-iodo-1-β-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR)
Manfredini S.;Baraldi P. G.;Durini E.;Vertuani S.;
2000
Abstract
Continuing our studies on the structure-activity relationships (SAR) of 4-iodo-1-β-D-ribofuranosyl-3-carbomethoxy pyrazole (IPCAR), the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-pyrazole derivs., with the 2'-deoxy-β-D-ribofuranosyl group and finally with the 2', 3'-dideoxy-D-glycero-pentofuranosyl-moiety. None of the new compds. display any interesting antiviral, antitumor, cytotoxicity, and antibacterial activities up to 300 μM.File in questo prodotto:
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