In the present study a pelletization process by mean of the GS coating system, was considered. Good yields of drug layering were obtained adjusting the quantity of both the drug powder to apply and the binder solution. Pellets containing ibuprofen were obtained following the optimal operating conditions and coated with the acrylic polymer Eudragit L30D in order to produce enteric polymer coated pellets. During its preparation the formulation never showed degradation of the drug; moreover, a low percentage of residual humidity was obtained. This study showed the good performance of the GS automated pan coating system in obtaining enteric-coated pellets prepared by powder layering technique using aqueous solutions.
Production of pellet by powder layering technique: coating with acrylic polymers for enteric drug release
CORTESI, Rita;ESPOSITO, Elisabetta;MENEGATTI, Enea;NASTRUZZI, Claudio
2001
Abstract
In the present study a pelletization process by mean of the GS coating system, was considered. Good yields of drug layering were obtained adjusting the quantity of both the drug powder to apply and the binder solution. Pellets containing ibuprofen were obtained following the optimal operating conditions and coated with the acrylic polymer Eudragit L30D in order to produce enteric polymer coated pellets. During its preparation the formulation never showed degradation of the drug; moreover, a low percentage of residual humidity was obtained. This study showed the good performance of the GS automated pan coating system in obtaining enteric-coated pellets prepared by powder layering technique using aqueous solutions.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
