The title compds. I [R = F, Cl, etc.; R1 = H, F, Cl, etc.; R2 = tert-Bu, CF3; n = 0, 1 or 2; X = O, S] are prepd. I [R = iodo; R1 = H; R2 = tert-butyl; n = 1] (prepd. in a multistep process from 4-hydroxy-3-methoxybenzylamine hydrochloride) significantly reduced capsaicin-induced wiping in rats.
Preparation of benzylthiourea derivatives as vanilloid TRPV1 receptor antagonists.
BARALDI, Pier Giovanni;BOREA, Pier Andrea;
2005
Abstract
The title compds. I [R = F, Cl, etc.; R1 = H, F, Cl, etc.; R2 = tert-Bu, CF3; n = 0, 1 or 2; X = O, S] are prepd. I [R = iodo; R1 = H; R2 = tert-butyl; n = 1] (prepd. in a multistep process from 4-hydroxy-3-methoxybenzylamine hydrochloride) significantly reduced capsaicin-induced wiping in rats.File in questo prodotto:
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