| Nome |
# |
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Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems, file e309ade0-bab4-3969-e053-3a05fe0a2c94
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119
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Pharmacological profile of nociceptin/orphanin FQ receptors interacting with G-proteins and β-arrestins 2, file e309ade0-a21b-3969-e053-3a05fe0a2c94
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87
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Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide s receptor activity, file e309ade0-6142-3969-e053-3a05fe0a2c94
|
65
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Characterisation of the novel mixed Mu-NOP peptide ligand dermorphin-N/OFQ (DeNo), file e309ade0-d488-3969-e053-3a05fe0a2c94
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63
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Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction, file e309ade1-0715-3969-e053-3a05fe0a2c94
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60
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A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism, file e309ade1-5a00-3969-e053-3a05fe0a2c94
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60
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The concise guide to pharmacology 2019/20: G protein-coupled receptors, file e309ade2-c531-3969-e053-3a05fe0a2c94
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59
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Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test, file e309ade4-d513-3969-e053-3a05fe0a2c94
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57
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NOP receptor pharmacological profile – A dynamic mass redistribution study, file e309ade2-0201-3969-e053-3a05fe0a2c94
|
56
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Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease, file e309ade1-0e3d-3969-e053-3a05fe0a2c94
|
49
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|
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands, file e309ade3-dd14-3969-e053-3a05fe0a2c94
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49
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A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials, file e309ade1-4d2b-3969-e053-3a05fe0a2c94
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48
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Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma, file e309ade0-c480-3969-e053-3a05fe0a2c94
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47
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Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review, file e309ade2-4c37-3969-e053-3a05fe0a2c94
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40
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Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies, file e309ade2-1260-3969-e053-3a05fe0a2c94
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37
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|
Neuropeptide S receptor ligands: a patent review (2005-2016), file e309ade3-a082-3969-e053-3a05fe0a2c94
|
36
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|
(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist, file e309ade4-7e91-3969-e053-3a05fe0a2c94
|
36
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|
In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505, file e309ade1-ef90-3969-e053-3a05fe0a2c94
|
34
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|
Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor, file e309ade2-11ed-3969-e053-3a05fe0a2c94
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34
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Modulation of Drosophila suzukii type 1 tyramine receptor (DsTAR1) by monoterpenes: a potential new target for next generation biopesticides, file e309ade2-9064-3969-e053-3a05fe0a2c94
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34
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Characterization of Halyomorpha halys TAR1 reveals its involvement in (E)-2-decenal pheromone perception, file e309ade4-e802-3969-e053-3a05fe0a2c94
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34
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Synthesis and Structure-Activity Relationships of (-)-cis-N-Normetazocine-Based LP1 Derivatives, file e309ade2-0b29-3969-e053-3a05fe0a2c94
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32
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Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors, file e309ade3-b3df-3969-e053-3a05fe0a2c94
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32
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Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2, file e309ade2-f967-3969-e053-3a05fe0a2c94
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28
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Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic- versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands, file e309ade3-b6ac-3969-e053-3a05fe0a2c94
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24
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Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic., file e309ade0-ab96-3969-e053-3a05fe0a2c94
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23
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Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors, file e309ade3-ecc7-3969-e053-3a05fe0a2c94
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21
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Synthesis, biological evaluation and docking studies of a novel class of sulfur-bridged diazabicyclo[3.3.1]nonanes, file dde59df4-4fe0-4961-8194-f6c697a38b89
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20
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The effect of guanethidine and local anaesthetics on the electrically stimulated mouse vas deferens, file e309ade0-8345-3969-e053-3a05fe0a2c94
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17
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Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults, file e309ade2-d66f-3969-e053-3a05fe0a2c94
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13
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Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?, file e309ade5-394a-3969-e053-3a05fe0a2c94
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13
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Neuropeptide S: A novel regulator of pain-related amygdala plasticity and behaviors, file e309ade0-4501-3969-e053-3a05fe0a2c94
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12
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Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration, file e309ade4-0a3d-3969-e053-3a05fe0a2c94
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12
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Biased versus Partial Agonism in the Search for Safer Opioid Analgesics, file e309ade4-45a7-3969-e053-3a05fe0a2c94
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12
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Plant-derived peptides rubiscolin-6, soymorphin-6 and their c-terminal amide derivatives: Pharmacokinetic properties and biological activity, file e309ade2-d705-3969-e053-3a05fe0a2c94
|
11
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Nociceptin and the putative ORL-1 ligand [Phe1psi(CH2-NH)Gly2)]nociceptin(1-13)NH2 exert anti-opiod effects in the Freund's adiuvant-induced arthritis rat model of chronic pain, file e309ade0-7c7d-3969-e053-3a05fe0a2c94
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10
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In vitro and in vivo pharmacological characterization of the synthetic opioid MT-45, file e309ade2-971e-3969-e053-3a05fe0a2c94
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10
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Detailed in vitro pharmacological characterization of the clinically viable nociceptin/orphanin FQ peptide receptor antagonist BTRX-246040, file e309ade2-ab4e-3969-e053-3a05fe0a2c94
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9
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The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor, file e309ade3-daf9-3969-e053-3a05fe0a2c94
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8
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Nociceptin Modulates Bronchoconstriction Induced by Sensory Nerve Activation in Mouse Lung., file e309ade0-2a4b-3969-e053-3a05fe0a2c94
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7
|
|
Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies., file e309ade0-340b-3969-e053-3a05fe0a2c94
|
7
|
|
The effects of neuropeptide S on general anesthesia in rats., file e309ade1-7c61-3969-e053-3a05fe0a2c94
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7
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|
Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic, file e309ade3-fb78-3969-e053-3a05fe0a2c94
|
7
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Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat., file e309ade0-339f-3969-e053-3a05fe0a2c94
|
6
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Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice., file e309ade0-3e2c-3969-e053-3a05fe0a2c94
|
6
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|
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112., file e309ade2-0913-3969-e053-3a05fe0a2c94
|
6
|
|
Conformation-activity relationship of neuropeptide S and some structural mutants: Helicity affects their interaction with the receptor, file e309ade0-22de-3969-e053-3a05fe0a2c94
|
5
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Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24., file e309ade0-2a4a-3969-e053-3a05fe0a2c94
|
5
|
|
Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68., file e309ade2-090f-3969-e053-3a05fe0a2c94
|
5
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|
Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia, file e309ade2-725e-3969-e053-3a05fe0a2c94
|
5
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|
Blockade of nociceptin/orphanin FQ signaling facilitates an active copying strategy due to acute and repeated stressful stimuli in mice, file e309ade2-d8bb-3969-e053-3a05fe0a2c94
|
5
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Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor, file e309ade0-3081-3969-e053-3a05fe0a2c94
|
4
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|
Neuropeptide S inhibits stress-stimulated faecal output in the rat., file e309ade0-340d-3969-e053-3a05fe0a2c94
|
4
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|
[(t)Bu-d-Gly(5)]NPS, a pure and potent antagonist of the neuropeptide S receptor: In vitro and in vivo studies, file e309ade0-3784-3969-e053-3a05fe0a2c94
|
4
|
|
Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze., file e309ade0-4aaf-3969-e053-3a05fe0a2c94
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4
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Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5, file e309ade0-b114-3969-e053-3a05fe0a2c94
|
4
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NOP-Targeted Peptide Ligands, file e309ade2-4d6f-3969-e053-3a05fe0a2c94
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4
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Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors, file e309ade2-4f09-3969-e053-3a05fe0a2c94
|
4
|
|
The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor, file e309ade3-8d0d-3969-e053-3a05fe0a2c94
|
4
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Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands, file 43c608e3-3b7b-45a9-9ae2-141bed32b171
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3
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|
Role of the ecto-nucleotidases in the cooperative effect of adenosine and neuropeptide-S on locomotor activity in mice., file e309ade0-33a2-3969-e053-3a05fe0a2c94
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3
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Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505)., file e309ade0-3781-3969-e053-3a05fe0a2c94
|
3
|
|
In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1, file e309ade0-4314-3969-e053-3a05fe0a2c94
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3
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Ligands Raise the Constraint That Limits Constitutive Activation in G Protein-coupled Opioid Receptors, file e309ade0-4864-3969-e053-3a05fe0a2c94
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3
|
|
Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness, file e309ade0-da03-3969-e053-3a05fe0a2c94
|
3
|
|
(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist, file e309ade2-202a-3969-e053-3a05fe0a2c94
|
3
|
|
Pharmacological Assays for Investigating the NOP Receptor, file e309ade2-532e-3969-e053-3a05fe0a2c94
|
3
|
|
Circadian variation in attempted suicide by deliberate self poisoning, file f6699744-20e8-4082-8247-20cc1983f2ad
|
3
|
|
The Insect Type 1 Tyramine Receptors: From Structure to Behavior, file 6a4e624a-d7ef-47d5-858a-e5aef748d275
|
2
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|
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands, file e309ade0-22e3-3969-e053-3a05fe0a2c94
|
2
|
|
In vitro and in vivo pharmacological characterization of the neuropeptide S receptor antagonist [D-Cys(tBu)5]NPS., file e309ade0-289d-3969-e053-3a05fe0a2c94
|
2
|
|
Morphology of segmented filamentous bacteria and their patterns of contact with the follicle-associated epithelium of the mouse terminal ileum: implications for the relationship with the immune system., file e309ade0-33a1-3969-e053-3a05fe0a2c94
|
2
|
|
[Dmt(1) ]N/OFQ(1-13)-NH(2) , a potent nociceptin/orphanin FQ and opioid receptor universal agonist., file e309ade0-3c8b-3969-e053-3a05fe0a2c94
|
2
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|
Pharmacological characterization of tachykinin tetrabranched derivatives, file e309ade0-3fd1-3969-e053-3a05fe0a2c94
|
2
|
|
Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111, file e309ade0-4198-3969-e053-3a05fe0a2c94
|
2
|
|
The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo., file e309ade0-440b-3969-e053-3a05fe0a2c94
|
2
|
|
null, file e309ade0-8a76-3969-e053-3a05fe0a2c94
|
2
|
|
Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic- versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands, file e309ade0-b93f-3969-e053-3a05fe0a2c94
|
2
|
|
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations, file e309ade1-09f6-3969-e053-3a05fe0a2c94
|
2
|
|
Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors, file e309ade1-97a2-3969-e053-3a05fe0a2c94
|
2
|
|
Neuropeptide S receptor ligands: a patent review (2005-2016), file e309ade1-ad8b-3969-e053-3a05fe0a2c94
|
2
|
|
Dopamine D1 and D2 receptors mediate neuropeptide S-induced antinociception in the mouse formalin test, file e309ade2-4743-3969-e053-3a05fe0a2c94
|
2
|
|
Blockade of NOP receptor modulates anxiety-related behaviors in mice exposed to inescapable stress, file e309ade2-a1db-3969-e053-3a05fe0a2c94
|
2
|
|
Modulation of Drosophila suzukii type 1 tyramine receptor (DsTAR1) by monoterpenes: a potential new target for next generation biopesticides, file e309ade2-c2e0-3969-e053-3a05fe0a2c94
|
2
|
|
Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease, file e309ade3-70d7-3969-e053-3a05fe0a2c94
|
2
|
|
Pharmacological characterization of naloxegol: In vitro and in vivo studies, file e309ade5-35a2-3969-e053-3a05fe0a2c94
|
2
|
|
Effects of chronic nociceptin/orphanin FQ exposure on cAMP accumulation and receptor density in Chinese, hamster ovary cells expressing human nociceptin/orphanin FQ receptors, file c62b10fe-3988-48a7-a83f-92881eb71e4c
|
1
|
|
Synthesis, Biological Activity and Molecular Docking of Chimeric Peptides Targeting Opioid and NOP Receptors, file d3b05279-a93f-4c95-a0d4-b9ec2faa132e
|
1
|
|
A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ., file e309ade0-2134-3969-e053-3a05fe0a2c94
|
1
|
|
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with C alpha,alpha-dialkylated amino acids, file e309ade0-22df-3969-e053-3a05fe0a2c94
|
1
|
|
Structure-activity studies on neuropeptide S - Identification of the amino acid residues crucial for receptor activation, file e309ade0-22e0-3969-e053-3a05fe0a2c94
|
1
|
|
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist, file e309ade0-22e1-3969-e053-3a05fe0a2c94
|
1
|
|
Urodynamic and clinical evidence of acute inhibitory effects of intravesical nociceptin/orphanin FQ on detrusor overactivity in humans: A pilot study, file e309ade0-22e9-3969-e053-3a05fe0a2c94
|
1
|
|
Structure-activity relationship of [Nphe(1)]-NC-(1-13)-NH2, a pure and selective nociceptin/orphanin FQ receptor antagonist, file e309ade0-22ee-3969-e053-3a05fe0a2c94
|
1
|
|
Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain, file e309ade0-22ef-3969-e053-3a05fe0a2c94
|
1
|
|
[Nphe(1)]-Nociceptin (1-13)-NH2, a nociceptin receptor antagonist, reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats, file e309ade0-22f3-3969-e053-3a05fe0a2c94
|
1
|
|
Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A, file e309ade0-22f7-3969-e053-3a05fe0a2c94
|
1
|
|
[Nphe(1)]NC(1-13)NH2 selectively antagonizes nociceptin/orphanin FQ-stimulated G-protein activation in rat brain, file e309ade0-22fb-3969-e053-3a05fe0a2c94
|
1
|
|
[Nphe(1)]nociceptin-(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum, file e309ade0-22fc-3969-e053-3a05fe0a2c94
|
1
|
|
Supraspinal and spinal effects of [Phe(1)psi(CH2-NH)Gly(2)]-nociceptin(1-13)-NH2 on nociception in the rat, file e309ade0-2302-3969-e053-3a05fe0a2c94
|
1
|
| Totale |
1.591 |