The risk of Hepatocellular carcinoma in patients with thalassemia. A review.

Oatients with thalassemia major, intermedia or double eterozygous with sickle cell disease are exposed to a major risk of developing hepatocellular carcinoma (HCC). Transfusion-transmitted viral infections and long standing iron overload represent principal carcinogenic risk factors. Every effort should be made to prevent tumor development, whose prognosis is usually dismal, or at least to make an early diagnosis. Screening should be performed regulary by means of ultra-sonography (US) and measurement of serum alpha-fetoprotein (AFP)

Data di pubblicazione: 2009
Titolo: The risk of Hepatocellular carcinoma in patients with thalassemia. A review.
Autori: E.Fabbri; G.Guerrini; C.Borgna
Rivista: ACTA MEDICA MEDITERRANEA
Parole Chiave: hepatocellular carcinoma; thalassemia syndrome; risk factors; iron overload; surveillance
Abstract: Oatients with thalassemia major, intermedia or double eterozygous with sickle cell disease are exposed to a major risk of developing hepatocellular carcinoma (HCC). Transfusion-transmitted viral infections and long standing iron overload represent principal carcinogenic risk factors. Every effort should be made to prevent tumor development, whose prognosis is usually dismal, or at least to make an early diagnosis. Screening should be performed regulary by means of ultra-sonography (US) and measurement of serum alpha-fetoprotein (AFP)
Handle: http://hdl.handle.net/11392/536145
Appare nelle tipologie:03.1 Articolo su rivista

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