HIV protease inhibitors (HIV-PI) have been shown to exert anti-angiogenic and anti-tumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi’s sarcoma were treated with Indinavir and followed for clinical evolution, drug pharmacokinetics and KS biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cell numbers, and a decrease of antibody titers against HHV8.

Clinical corse of classic Kaposi’s sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir.

BORGHI, Alessandro;
2009

Abstract

HIV protease inhibitors (HIV-PI) have been shown to exert anti-angiogenic and anti-tumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi’s sarcoma were treated with Indinavir and followed for clinical evolution, drug pharmacokinetics and KS biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cell numbers, and a decrease of antibody titers against HHV8.
Monini, P; Sgadari, C; Grosso, Mg; Bellino, S; Di Biagio, A; Toschi, E; Bacigalupo, I; Sabbatucci, M; Cencioni, G; Salvi, E; Leone, P; Ensoli, B; the Concerted Action on Kaposi’s Sarcoma: Barillari, G; Moracci, G; Castelli, L; Gatti, G; Brambilla, L; Bramati, M; Ferrucci, S; De Pità, O; Pilla, Ma; Di Carlo, A; Giuliani, M; Cottoni, F; Cuccuru, Ma; Calmieri, S; Clerico, R; Potenza, C; Tirelli, U; Simonelli, C; Martellotta, F; Strumia, R; Borghi, Alessandro; Del Giacco, S; Moi, L; Piludu, G; Siriani, Mc; Campagna, M; Sarmati, L; Androni, M; Bianchini, G; Sheldon, J; Milzer, J; Schulz, T.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/534709
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