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EnglishTetra benzamidine derivatives were found to inhibit proteinase activity, cell proliferation and accumulation of the Ha-ras-1 mRNA in the FHO6T1-1 Chinese Hamster cell line, transformed with the activated human T24-Ha-ras-1 oncogene. Di- and Tri- benzamidine derivatives were also found to be potent inhibitors of proliferation of FHO6T1-1 cells. These latter compounds could be proposed as useful substrates in the synthesis of drug-conjugated monoclonal antibodies or growth factors.
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| Data di pubblicazione: | 1988 | |
| Titolo: | Effects of benzamidine derivatives on Ha-ras-1 mRNA accumulation in a Chinese hamster cell line transformed with the activated human T24 Ha-ras-1 oncogene. | |
| Autori: | Nastruzzi C; Feriotto G; Spandidos D; Anzanel D; Ferroni R; Guarneri M; Barbieri R; Gambari R. | |
| Rivista: | ANTICANCER RESEARCH | |
| Parole Chiave: | Tetra benzamidine derivatives; FHO6T1-1 Chinese Hamster cell line; proteinase activity; cell proliferation; Ha-ras-1 oncogene. | |
| Abstract: | Tetra benzamidine derivatives were found to inhibit proteinase activity, cell proliferation and accumulation of the Ha-ras-1 mRNA in the FHO6T1-1 Chinese Hamster cell line, transformed with the activated human T24-Ha-ras-1 oncogene. Di- and Tri- benzamidine derivatives were also found to be potent inhibitors of proliferation of FHO6T1-1 cells. These latter compounds could be proposed as useful substrates in the synthesis of drug-conjugated monoclonal antibodies or growth factors. | |
| Handle: | http://hdl.handle.net/11392/534515 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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