Methacholine (MCH) is used to perform the bronchial challenge test for the diagnosis of asthma where it is necessary to determine if an individual has hyper-responsive airways. The aim of this work was to develop a new method for MCH challenge test using pre-metered respirable MCH powders at different doses for performing brochial challenge studies. The availability of a series of pre-metered doses gives greater control on aerosolized dose and fine particle dose (respirable dose), improving the accuracy and repeatability of the test. A dosimetric challenge test, comparing MCH dry powder and MCH solution for asthma detection, was performed in eighteen subjects.

A Clinical Study of a Methacholine Dry Powder for the Bronchial Challenge Test

COLOMBO, Gaia;
2008

Abstract

Methacholine (MCH) is used to perform the bronchial challenge test for the diagnosis of asthma where it is necessary to determine if an individual has hyper-responsive airways. The aim of this work was to develop a new method for MCH challenge test using pre-metered respirable MCH powders at different doses for performing brochial challenge studies. The availability of a series of pre-metered doses gives greater control on aerosolized dose and fine particle dose (respirable dose), improving the accuracy and repeatability of the test. A dosimetric challenge test, comparing MCH dry powder and MCH solution for asthma detection, was performed in eighteen subjects.
9781933722214
9781933722221
9781933722238
Hyperresponsiveness; bronchoconstriction; clinical study; DPI; methacholine; challenge test
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/534041
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