Local anesthesia is intended as all technique that makes a region or part of the body insensitive to pain without loss of consciousness. It is produced by injection of a local anesthetic drug (LAs) in solution into the epidural or subarachnoid spaces or near specific nerves (nerve block). Clinically, prolonged duration of anesthesia and limited systemic and local toxicity are desirable. These goals may be achieved by means of slow release formulations that maintain active drug concentrations at the injection site for longer periods of time. In addition, local anesthetics can be given in association with non-anesthetic drugs that were shown to have a synergistic effect with LAs. Here, the performances of three different formulations containing bupivacaine are investigated in vivo (rats) with respect to both in vivo sciatic nerve block and tissue reaction. The aim of this research was to develop an injectable formulation for bupivacaine administration able to induce nerve block lasting from several hours to days or weeks. At the end of the work, different durations of block were obtained with the three formulations investigated and local tissue reaction at injection site was highly dependent on the system’s composition and degradation profile. Nevertheless, all these systems may be useful to provide prolonged duration local anesthesia adequate to various clinical conditions.

Strategies in bupivacaine delivery for prolonged duration local anesthesia

COLOMBO, Gaia;
2006

Abstract

Local anesthesia is intended as all technique that makes a region or part of the body insensitive to pain without loss of consciousness. It is produced by injection of a local anesthetic drug (LAs) in solution into the epidural or subarachnoid spaces or near specific nerves (nerve block). Clinically, prolonged duration of anesthesia and limited systemic and local toxicity are desirable. These goals may be achieved by means of slow release formulations that maintain active drug concentrations at the injection site for longer periods of time. In addition, local anesthetics can be given in association with non-anesthetic drugs that were shown to have a synergistic effect with LAs. Here, the performances of three different formulations containing bupivacaine are investigated in vivo (rats) with respect to both in vivo sciatic nerve block and tissue reaction. The aim of this research was to develop an injectable formulation for bupivacaine administration able to induce nerve block lasting from several hours to days or weeks. At the end of the work, different durations of block were obtained with the three formulations investigated and local tissue reaction at injection site was highly dependent on the system’s composition and degradation profile. Nevertheless, all these systems may be useful to provide prolonged duration local anesthesia adequate to various clinical conditions.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/534027
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