Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.

UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.

FABBRI, Enrica;VOLINIA, Stefano;GAMBARI, Roberto;BOTTONI, Arianna;
2009

Abstract

Four hundred and eighty-one ultraconserved sequences (UCRs) longer than 200 bases were discovered in the genomes of human, mouse and rat. These are DNA sequences showing 100% identity among the three species. UCRs are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs (miRNAs). Here we present UCbase & miRfunc, the first database which provides ultraconserved sequences data and shows miRNA function. Also, it links UCRs and miRNAs with the related human disorders and genomic properties. The current release contains over 2000 sequences from three species (human, mouse and rat). As a web application, UCbase & miRfunc is platform independent and it is accessible at http://microrna.osu.edu/.UCbase4.
Taccioli, C; Fabbri, Enrica; Visone, R; Volinia, Stefano; Calin, Ga; Fong, Ly; Gambari, Roberto; Bottoni, Arianna; Acunzo, M; Hagan, J; Iorio, Mv; Piovan, C; Romano, G; Croce, C. M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/533635
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