Whilst estrogens induce cancers in rodent bioassays and in spite of several studies on the pathogenetic mechanism, it is still unclear the relative role of genotoxic (such as metabolic redox cycling to generate free radicals such as superoxide and epigenetic action (growth stimulation, modulation of oncogene expression, metabolic cooxidation of arachidonic acids to prostaglandins). Here we reported the in vitro genotoxic evaluation of the early estradiol catecholoestrogens metabolites: 4OH-Estradiol, 2OH-Estradiol, 2OH-Estrone, 4OH-Estrone, 16-alfaOH-Estrone.

Genotoxicity of natural catecholoestrogens assessed by cytogenetic in vitro tests.

COLAMUSSI, Maria Luisa;ROSSI, Damiano;AIELLO, Vincenzo;SENSI, Alberto;PAGANETTO, Guglielmo;
2003

Abstract

Whilst estrogens induce cancers in rodent bioassays and in spite of several studies on the pathogenetic mechanism, it is still unclear the relative role of genotoxic (such as metabolic redox cycling to generate free radicals such as superoxide and epigenetic action (growth stimulation, modulation of oncogene expression, metabolic cooxidation of arachidonic acids to prostaglandins). Here we reported the in vitro genotoxic evaluation of the early estradiol catecholoestrogens metabolites: 4OH-Estradiol, 2OH-Estradiol, 2OH-Estrone, 4OH-Estrone, 16-alfaOH-Estrone.
Genotoxicity; Catecholoestrogens; Cytogenetic test in vitro; Cytokinesis Block Micronucleus (CBMN); Sister Chromatid Exchanges (SCE)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/533046
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