Immunization interventions taken over the years have influenced the epidemiology of the various diseases with a reduction in morbidity and generally a lower spreading of the corresponding infectious agents. In some cases, problems related to the length of protection provided by the vaccines and the consequent need not just to optimise vaccinations in newborns but also to plan booster vaccinations have been observed. Boosters are essential to avoid the creation of clusters of newly susceptible subjects among adolescents and adults, previously successfully vaccinated, due both to the decay of immunity and the reduced spreading of microrganisms. The 2005-2007 Italian National Vaccination Plan (INVP) has underlined the importance of reaching and maintaining high vaccination coverage rates in childhood and of planning booster vaccinations for tetanus, diphtheria, pertussis and polio, beginning from pre-school age and every ten years in adult life. Two timeframes of intervention have been identified: 5-6 years (for tetanus, diphtheria, pertussis and polio) and 11-15 years of age (for tetanus, diphtheria and pertussis). The availability of combined vaccines for tetanus, diphtheria, pertussis and polio boosters is therefore an important resource. Two products, differing in antigen content and indications for use (DTaP-IPV and dTap-IPV), have been developed for booster immunisation against tetanus, diphtheria, pertussis and polio. The combined DTaP-IPV and dTap-IPV vaccines, with an excellent safety and immunogenicity profile, represent an important resource to guarantee vaccination continuity.

The value of booster vaccinations against diphtheria, tetanus, pertussis and poliomyelitis.

GABUTTI, Giovanni
2008

Abstract

Immunization interventions taken over the years have influenced the epidemiology of the various diseases with a reduction in morbidity and generally a lower spreading of the corresponding infectious agents. In some cases, problems related to the length of protection provided by the vaccines and the consequent need not just to optimise vaccinations in newborns but also to plan booster vaccinations have been observed. Boosters are essential to avoid the creation of clusters of newly susceptible subjects among adolescents and adults, previously successfully vaccinated, due both to the decay of immunity and the reduced spreading of microrganisms. The 2005-2007 Italian National Vaccination Plan (INVP) has underlined the importance of reaching and maintaining high vaccination coverage rates in childhood and of planning booster vaccinations for tetanus, diphtheria, pertussis and polio, beginning from pre-school age and every ten years in adult life. Two timeframes of intervention have been identified: 5-6 years (for tetanus, diphtheria, pertussis and polio) and 11-15 years of age (for tetanus, diphtheria and pertussis). The availability of combined vaccines for tetanus, diphtheria, pertussis and polio boosters is therefore an important resource. Two products, differing in antigen content and indications for use (DTaP-IPV and dTap-IPV), have been developed for booster immunisation against tetanus, diphtheria, pertussis and polio. The combined DTaP-IPV and dTap-IPV vaccines, with an excellent safety and immunogenicity profile, represent an important resource to guarantee vaccination continuity.
Gabutti, Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/531802
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