Massive changes in the concentration of C-reactive protein (CRP), a well recognied positie acute phase protein, are known take place rapidly in bdy fluids during the onset of inflammatory and infective diseaeses. This process results into the accumulation of CRP at the sites of the lesions and is classically closely linked to protective effects through targeted activation of complement and thereby clearance of bacteria and necrotic cell debris. Data collected during the last couple of years has documented an unexpected role of this protein as a major pathogenic element in atherosclerosis, which is now considered as an inflammation of the arterial endothelian lining. In this disease, intimal and muscolar lesions are accompained by deposition of CRP, local activation of complement, recruiment of phagocytic cells and opposite effects on the final plate stability depending on the balance between proteolytic processing and collagen deposition. Major effects are now played to reduce pharmacologically the levels of CRP in the blood stream and to counteract its local activation in order to control the development of this dangerous inflammatory disease.

C. Reactive Protein: not only a marker, but a possible physiopathologic agent in chronic vascular inflammation

BERGAMINI, Carlo;DONDI, Alessia;GAMBETTI, Stefania;CERVELLATI, Carlo;
2004

Abstract

Massive changes in the concentration of C-reactive protein (CRP), a well recognied positie acute phase protein, are known take place rapidly in bdy fluids during the onset of inflammatory and infective diseaeses. This process results into the accumulation of CRP at the sites of the lesions and is classically closely linked to protective effects through targeted activation of complement and thereby clearance of bacteria and necrotic cell debris. Data collected during the last couple of years has documented an unexpected role of this protein as a major pathogenic element in atherosclerosis, which is now considered as an inflammation of the arterial endothelian lining. In this disease, intimal and muscolar lesions are accompained by deposition of CRP, local activation of complement, recruiment of phagocytic cells and opposite effects on the final plate stability depending on the balance between proteolytic processing and collagen deposition. Major effects are now played to reduce pharmacologically the levels of CRP in the blood stream and to counteract its local activation in order to control the development of this dangerous inflammatory disease.
Bergamini, Carlo; Dondi, Alessia; Gambetti, Stefania; Cervellati, Carlo; V., Lanzara
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/531374
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