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EnglishChronic obstructive pulmonary disease (COPD) patients have an increased number of T cells within their lungs. It is unknown whether these T cells, remain there forever or if there is a continuous turnover from the blood. In the adult, there is a significant T lymphocytopoiesis from the thymus producing cells known as recent thymic emigrants (RTEs). T cell receptor excision circles (TREC) are a marker of RTEs. We investigated the number of TREC in blood from patients with untreated stable, mild to moderate COPD (n=6) compared with age-matched smokers with normal lung function (n=6) and nonsmokers (n=8). The results showed variable expression of TREC in each subject group and no significant difference between TREC expression in any group of subjects. Changes in T-cell numbers in the lung of stable COPD patients, may reflect prolonged survival or proliferation of these cells within the lung rather than continuous recruitment from the blood.
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| Data di pubblicazione: | 2008 | |
| Titolo: | Recent thymic emigrants do not account for the increased number of T-cells seen in the lungs of stable chronic obstructive pulmonary disease | |
| Autori: | Caramori G.; Ito K.; Jazrawi E.; Casolari P.; Chung K.F.; Barnes P.J.; Adcock I.M.; Papi A. | |
| Rivista: | THE OPEN PATHOLOGY JOURNAL | |
| Parole Chiave: | COPD; T cells | |
| Abstract: | Chronic obstructive pulmonary disease (COPD) patients have an increased number of T cells within their lungs. It is unknown whether these T cells, remain there forever or if there is a continuous turnover from the blood. In the adult, there is a significant T lymphocytopoiesis from the thymus producing cells known as recent thymic emigrants (RTEs). T cell receptor excision circles (TREC) are a marker of RTEs. We investigated the number of TREC in blood from patients with untreated stable, mild to moderate COPD (n=6) compared with age-matched smokers with normal lung function (n=6) and nonsmokers (n=8). The results showed variable expression of TREC in each subject group and no significant difference between TREC expression in any group of subjects. Changes in T-cell numbers in the lung of stable COPD patients, may reflect prolonged survival or proliferation of these cells within the lung rather than continuous recruitment from the blood. | |
| Handle: | http://hdl.handle.net/11392/530186 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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