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EnglishAbstract The aim of this paper is to report our clinical experience of Sweet's syndrome, a severe dermatological disease which may be extremely important to recognize for the early diagnosis of a neoplastic disorder. Eleven patients affected by Sweet's syndrome, treated at the Department of Dermatology, University of Ferrara, Ferrara, Italy, during 1998 to 2004, were evaluated. A retrospective analysis was performed. Data on age, sex distribution, clinical data, histopathological and immunohistochemical findings and therapy were collected. We observed one patient with idiopathic form, 5 patients affected by the para-inflammatory variant and 5 para-neoplastic cases (with haemoproliferative diseases). The cases with the para-inflammatory form were affected by minor infectious manifestations. Prolonged follow-up is necessary to verify that a case of idiopathic variant is not really a paraneoplastic form. Based on immunohistochemical analysis, we cannot exclude that true histiocytes, immunoreactive for CD68/PGM, infiltrate the dermis in Sweet's syndrome lesions. © 2008 Acta Dermato-Venereologica.
| Data di pubblicazione: | 2008 | |
| Titolo: | Sweet's syndrome: a retrospective clinical, histopathological and immunohistochemical analysis of 11 cases | |
| Autori: | Corazza, Monica; Lauriola, Maria Michela; Borghi, Alessandro; Marzola, Andrea; Virgili, Anna | |
| Rivista: | ACTA DERMATO-VENEREOLOGICA | |
| Keywords: | Sweet's syndrome, neutrophilic dermatosis, histopathology, paraneoplastic form | |
| Abstract in inglese: | Abstract The aim of this paper is to report our clinical experience of Sweet's syndrome, a severe dermatological disease which may be extremely important to recognize for the early diagnosis of a neoplastic disorder. Eleven patients affected by Sweet's syndrome, treated at the Department of Dermatology, University of Ferrara, Ferrara, Italy, during 1998 to 2004, were evaluated. A retrospective analysis was performed. Data on age, sex distribution, clinical data, histopathological and immunohistochemical findings and therapy were collected. We observed one patient with idiopathic form, 5 patients affected by the para-inflammatory variant and 5 para-neoplastic cases (with haemoproliferative diseases). The cases with the para-inflammatory form were affected by minor infectious manifestations. Prolonged follow-up is necessary to verify that a case of idiopathic variant is not really a paraneoplastic form. Based on immunohistochemical analysis, we cannot exclude that true histiocytes, immunoreactive for CD68/PGM, infiltrate the dermis in Sweet's syndrome lesions. © 2008 Acta Dermato-Venereologica. | |
| Digital Object Identifier (DOI): | 10.2340/00015555-0526 | |
| Handle: | http://hdl.handle.net/11392/529224 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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