The objective of the study was to prepare lipid microparticles loaded with the sunscreen agent, 4-methylbenzylidene camphor, to achieve decreased skin penetration of this UV filter. The microparticles were produced by the melt dispersion technique using tristearin as lipidic material and hydrogenated phosphatidylcholine as the surfactant. The obtained particles were characterized by scanning electron microscopy and differential scanning calorimetry. Rlease of 4-methylbenzylidene camphor from the particles was found to be slower than its dissolution rate. The influence of the lipid particles on percutaneous penetration was evaluated after ther introduction in a model topical formulation (emulsion). In-vitro measurements indicated that the release and diffusion of 4-methylbenzylidene camphor was decreased by 66.7-77.3% with the particle formulation. In-vivo human skin penetration was investigated by tape-stripping. The amount of sunscreen penetrating into the stratum corneum was greater for the emulsion containing the non-encapsulated 4-methylbenzylidene camphor (36.55% of the applied dose) compared with the formulation with the sunscreen-loaded microparticles (24.57% of the applied dose).
Influence of solid lipid microparticle carriers on skin penetration of the sunscreen agent, 4-methylbenzylidene camphor
SCALIA, Santo;MEZZENA, Matteo;
2007
Abstract
The objective of the study was to prepare lipid microparticles loaded with the sunscreen agent, 4-methylbenzylidene camphor, to achieve decreased skin penetration of this UV filter. The microparticles were produced by the melt dispersion technique using tristearin as lipidic material and hydrogenated phosphatidylcholine as the surfactant. The obtained particles were characterized by scanning electron microscopy and differential scanning calorimetry. Rlease of 4-methylbenzylidene camphor from the particles was found to be slower than its dissolution rate. The influence of the lipid particles on percutaneous penetration was evaluated after ther introduction in a model topical formulation (emulsion). In-vitro measurements indicated that the release and diffusion of 4-methylbenzylidene camphor was decreased by 66.7-77.3% with the particle formulation. In-vivo human skin penetration was investigated by tape-stripping. The amount of sunscreen penetrating into the stratum corneum was greater for the emulsion containing the non-encapsulated 4-methylbenzylidene camphor (36.55% of the applied dose) compared with the formulation with the sunscreen-loaded microparticles (24.57% of the applied dose).I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
