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EnglishIn the isolated and perfused rabbit heart ischemia induced a rapid decline of contractility, associated with a reduction of the content of tissue GSH with no significant changes in GSSG. Reperfusion induced a small recovery of contractility, a substantial release of total glutathione and a further decrease in the content of tissue GSH with a significant increase of tissue GSSG. Glutathione reductase and glutathione peroxidase activities were not affected by ischemia and reperfusion. This study suggests a possible role for glutathione in the determination of functional damage induced by myocardial ischemia and reperfusion.
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| Data di pubblicazione: | 1985 | |
| Titolo: | Changes in the cardiac glutathione status after ischemia and reperfusion. | |
| Autori: | S. Curello; C. Ceconi; C. Bigoli; R. Ferrari; A. Albertini; C. Guarnieri | |
| Rivista: | EXPERIENTIA | |
| Abstract: | In the isolated and perfused rabbit heart ischemia induced a rapid decline of contractility, associated with a reduction of the content of tissue GSH with no significant changes in GSSG. Reperfusion induced a small recovery of contractility, a substantial release of total glutathione and a further decrease in the content of tissue GSH with a significant increase of tissue GSSG. Glutathione reductase and glutathione peroxidase activities were not affected by ischemia and reperfusion. This study suggests a possible role for glutathione in the determination of functional damage induced by myocardial ischemia and reperfusion. | |
| Handle: | http://hdl.handle.net/11392/524584 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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