The present invention relates to Pt complexes contg. bile acids derivs., I (n = 0, 1; A = C, CHCH), having antitumor activity. For example, I (n = 0, A = C) was prepd. in 84 % yield by the reaction of dehydrochloric acid with L-tartaric acid in several steps to give the triacid which was reacted with [Pt(NH3)2(H2O)2](NO3)2. Pharmaceutical compns. contg. I are claimed.
Platinum complexes containing chemically modified bile acids, having antitumor activity.
MEDICI, Alessandro;
2003
Abstract
The present invention relates to Pt complexes contg. bile acids derivs., I (n = 0, 1; A = C, CHCH), having antitumor activity. For example, I (n = 0, A = C) was prepd. in 84 % yield by the reaction of dehydrochloric acid with L-tartaric acid in several steps to give the triacid which was reacted with [Pt(NH3)2(H2O)2](NO3)2. Pharmaceutical compns. contg. I are claimed.File in questo prodotto:
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