Semi permissive mouse, rabbit and monkey cells were stably transformed by BK virus (BKV). The specificity of transformation was demonstrated by the presence of BKV tumor (T) antigen in nuclei of transformed cells and by virus rescue with Sendai virus mediated fusion or transfection. Two out of 7 BKV transformed cell lines were oncogenic. Permissive human cells were only abortively transformed by BKV, since morphologically modified cells persisted in culture for a few passages and eventually died.
Stable transformation of mouse, rabbit and monkey cells and abortive transformation of human cells by BK virus, a human papovavirus
BORGATTI, Monica;CORALLINI, Alfredo;CASSAI, Enzo;GROSSI, Maria Pia;BARBANTI BRODANO, Giuseppe;
1978
Abstract
Semi permissive mouse, rabbit and monkey cells were stably transformed by BK virus (BKV). The specificity of transformation was demonstrated by the presence of BKV tumor (T) antigen in nuclei of transformed cells and by virus rescue with Sendai virus mediated fusion or transfection. Two out of 7 BKV transformed cell lines were oncogenic. Permissive human cells were only abortively transformed by BKV, since morphologically modified cells persisted in culture for a few passages and eventually died.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
