Polycaryocytogenic (P) and non-polycaryocytogenic, or aggregating (A), stable variants were selected from a herpes simplex virus type 1 (HSV-1) and from a herpes simplex virus type 2 (HSV-2) which had not been deliberately exposed to known mutagenic agents. The P variant of HSV-1 (F<inf>P</inf>) differed from the A variant (Fa) in polypeptides and glycoprotein patterns, but no gross differences were evident between the two variants of HSV-2 (G<inf>P</inf> and G<inf>A</inf>). Each P variant proved more ‘specific’ than each A variant in immune neutralization tests. At high multiplicity, G<inf>P</inf> produced polycaryocytes but F<inf>P</inf> did not. Virulence tests in mice showed F<inf>P</inf> to be much more virulent than F<inf>A</inf> but G<inf>A</inf> to be more virulent than G<inf>P</inf>. Finally, A and P variants of each type could not be differentiated with respect to thermal resistance of virions, capacity to grow at high temperature, and buoyant density of DNA. © 1975 by S. Karger AG, Basel.

Plaque dissociation of herpes sinplex viruses: biochemical and biological characters of the viral variants

CASSAI, Enzo;MANSERVIGI, Roberto;CORALLINI, Alfredo;
1975

Abstract

Polycaryocytogenic (P) and non-polycaryocytogenic, or aggregating (A), stable variants were selected from a herpes simplex virus type 1 (HSV-1) and from a herpes simplex virus type 2 (HSV-2) which had not been deliberately exposed to known mutagenic agents. The P variant of HSV-1 (FP) differed from the A variant (Fa) in polypeptides and glycoprotein patterns, but no gross differences were evident between the two variants of HSV-2 (GP and GA). Each P variant proved more ‘specific’ than each A variant in immune neutralization tests. At high multiplicity, GP produced polycaryocytes but FP did not. Virulence tests in mice showed FP to be much more virulent than FA but GA to be more virulent than GP. Finally, A and P variants of each type could not be differentiated with respect to thermal resistance of virions, capacity to grow at high temperature, and buoyant density of DNA. © 1975 by S. Karger AG, Basel.
1975
Cassai, Enzo; Manservigi, Roberto; Corallini, Alfredo; Terni, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/523167
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