Polycaryocytogenic (P) and non-polycaryocytogenic, or aggregating (A), stable variants were selected from a herpes simplex virus type 1 (HSV-1) and from a herpes simplex virus type 2 (HSV-2) which had not been deliberately exposed to known mutagenic agents. The P variant of HSV-1 (F<inf>P</inf>) differed from the A variant (Fa) in polypeptides and glycoprotein patterns, but no gross differences were evident between the two variants of HSV-2 (G<inf>P</inf> and G<inf>A</inf>). Each P variant proved more ‘specific’ than each A variant in immune neutralization tests. At high multiplicity, G<inf>P</inf> produced polycaryocytes but F<inf>P</inf> did not. Virulence tests in mice showed F<inf>P</inf> to be much more virulent than F<inf>A</inf> but G<inf>A</inf> to be more virulent than G<inf>P</inf>. Finally, A and P variants of each type could not be differentiated with respect to thermal resistance of virions, capacity to grow at high temperature, and buoyant density of DNA. © 1975 by S. Karger AG, Basel.
Plaque dissociation of herpes sinplex viruses: biochemical and biological characters of the viral variants
CASSAI, Enzo;MANSERVIGI, Roberto;CORALLINI, Alfredo;
1975
Abstract
Polycaryocytogenic (P) and non-polycaryocytogenic, or aggregating (A), stable variants were selected from a herpes simplex virus type 1 (HSV-1) and from a herpes simplex virus type 2 (HSV-2) which had not been deliberately exposed to known mutagenic agents. The P variant of HSV-1 (FI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
