'Folate-pathway gene variants in cancer: haematological malignancies' is a book designed to assemble basic concepts investigating and furnishing new insights of biochemistry, molecular biology, clinical understanding and progresses, pharmacogenetics and pharmacogenomics in the field of cancer with particular addressing towards haematological malignancies. In particular, all details are focused on folate vitamins, the enzymes that processed them, the gene variations (polymorphisms) responsible for functional changes in the activities or in other related characteristics of the molecule. Folate is a key molecule for cell cycle, particularly for high proliferating cells, as cancerous cells. Folate has been the target for classical antifolate drugs and today it is the molecule by which new alternative treatment strategies against cancer will be developed by means of ’vitamin targeted chemotherapeutic conjugates’. This, together with pharmacogenetic approaches is aimed to develop personalized and tailored therapies to avoid, modulate or reduce the well known negative side effects due to excessive and non-optimized chemotherapy. The book is presented as a concise series of chapters linked together by an ideal fil rouge starting from biochemical notes of folate metabolism and description of the main involved enzymes. This is followed by discussion of the related genes characterized by numerous variants (most of them single nucleotide polymorphisms; SNPs), description of the main haematological cancers candidate to antifolate drugs, to land to epigenetics, pharmacogenetics, nutrigenetics, microarrays and nanotechnology. All this, is potentially useful for precocious and more definite diagnosis and treatment in cancer. Each chapter starts with a brief introduction and recalling of the basic folate related information requisite for a better and complete comprehension of the section independently from the reading of the whole book. This book is indicated for all clinicians, haematologists-oncologists, biologists, geneticists, and students in bio-medical field eager to be introduced in practical applications (clinical and technological) derived from the genome era. To be far from a complete and exhaustive opera, this book furnishes also the basic principles essential to handle and investigate classical neoplastic disorders with the help of new molecular tools originated from recent advanced researches no more prerogative of few and specialised molecular labs but more and more common in the today reality.

Folate-pathway gene variants in cancer: haematological malignancies.

GEMMATI, Donato
2008

Abstract

'Folate-pathway gene variants in cancer: haematological malignancies' is a book designed to assemble basic concepts investigating and furnishing new insights of biochemistry, molecular biology, clinical understanding and progresses, pharmacogenetics and pharmacogenomics in the field of cancer with particular addressing towards haematological malignancies. In particular, all details are focused on folate vitamins, the enzymes that processed them, the gene variations (polymorphisms) responsible for functional changes in the activities or in other related characteristics of the molecule. Folate is a key molecule for cell cycle, particularly for high proliferating cells, as cancerous cells. Folate has been the target for classical antifolate drugs and today it is the molecule by which new alternative treatment strategies against cancer will be developed by means of ’vitamin targeted chemotherapeutic conjugates’. This, together with pharmacogenetic approaches is aimed to develop personalized and tailored therapies to avoid, modulate or reduce the well known negative side effects due to excessive and non-optimized chemotherapy. The book is presented as a concise series of chapters linked together by an ideal fil rouge starting from biochemical notes of folate metabolism and description of the main involved enzymes. This is followed by discussion of the related genes characterized by numerous variants (most of them single nucleotide polymorphisms; SNPs), description of the main haematological cancers candidate to antifolate drugs, to land to epigenetics, pharmacogenetics, nutrigenetics, microarrays and nanotechnology. All this, is potentially useful for precocious and more definite diagnosis and treatment in cancer. Each chapter starts with a brief introduction and recalling of the basic folate related information requisite for a better and complete comprehension of the section independently from the reading of the whole book. This book is indicated for all clinicians, haematologists-oncologists, biologists, geneticists, and students in bio-medical field eager to be introduced in practical applications (clinical and technological) derived from the genome era. To be far from a complete and exhaustive opera, this book furnishes also the basic principles essential to handle and investigate classical neoplastic disorders with the help of new molecular tools originated from recent advanced researches no more prerogative of few and specialised molecular labs but more and more common in the today reality.
2008
9788178953397
HEMATOLOGY; PHARMACOGENETICS; CANCER; FOLATE; SNPs
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/521678
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