PURPOSE: To report the occurrence of acute cataract in children with insulin dependent diabetes mellitus (IDDM). DESIGN: Observational case series. METHODS: Three newly diagnosed IDDM children, who presented visual loss at the onset of the disease, were investigated. Accurate metabolic and ophthalmologic examinations were performed. RESULTS: All these cases shared some critical characteristics: male gender, severe ketoacidosis, hyperglycemia, elevated level of glycated hemoglobin, and bilateral cataract. Cataracts were so advanced to require surgery in both eyes of all patients. CONCLUSIONS: The pathogenesis of acute cataract in IDDM children could be due to the synergism among osmotic hydration of the lens, secondary to hyperglycemia, ketoacidosis, and oxidative stress.

Bilateral isolated acute cataracts in three newly diagnosed insulin dependent diabetes mellitus young patients.

PARMEGGIANI, Francesco
2007

Abstract

PURPOSE: To report the occurrence of acute cataract in children with insulin dependent diabetes mellitus (IDDM). DESIGN: Observational case series. METHODS: Three newly diagnosed IDDM children, who presented visual loss at the onset of the disease, were investigated. Accurate metabolic and ophthalmologic examinations were performed. RESULTS: All these cases shared some critical characteristics: male gender, severe ketoacidosis, hyperglycemia, elevated level of glycated hemoglobin, and bilateral cataract. Cataracts were so advanced to require surgery in both eyes of all patients. CONCLUSIONS: The pathogenesis of acute cataract in IDDM children could be due to the synergism among osmotic hydration of the lens, secondary to hyperglycemia, ketoacidosis, and oxidative stress.
2007
Costagliola, C; Dell'Omo, R; Prisco, F; Iafusco, D; Landolfo, F; Parmeggiani, Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/521009
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