During the past few years molecular genetics has made rapid advances in the knowledge of the mechanisms involved in the pathogenesis of human malignancies. Development of large bowel carcinoma apppears to take place by stepwise accumulation of multiple genetic alterations during the progression form normal colon to adenoma to carcinoma. Two mechanisms are involved in the pathogenesis of human malignancies: oncogene activation and suppressor gene inactivation. Ras and myc oncogenes are the most studied: mutation of ras is found in 50% of colon cancers, overexpression of c-myc is found in 80% and inactivation of suppressor genes is noted in wave than 70% of tumors. Understanding these genetic factors and how they influence cellular function will have an important role on the diagnostic, prognostic and therapeutic management of patients with colon rectal carcinoma identifying high risk populations.
ALTERAZIONI GENETICHE E CARCINOMA DEL GROSSO INTESTINO
OCCHIONORELLI, Savino
1993
Abstract
During the past few years molecular genetics has made rapid advances in the knowledge of the mechanisms involved in the pathogenesis of human malignancies. Development of large bowel carcinoma apppears to take place by stepwise accumulation of multiple genetic alterations during the progression form normal colon to adenoma to carcinoma. Two mechanisms are involved in the pathogenesis of human malignancies: oncogene activation and suppressor gene inactivation. Ras and myc oncogenes are the most studied: mutation of ras is found in 50% of colon cancers, overexpression of c-myc is found in 80% and inactivation of suppressor genes is noted in wave than 70% of tumors. Understanding these genetic factors and how they influence cellular function will have an important role on the diagnostic, prognostic and therapeutic management of patients with colon rectal carcinoma identifying high risk populations.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
