Synthesis of a new series of nucleoside analogs with antiflaviviridae activity and their interaction with RNA-dependent RNA-polymerase

Among the plethora of synthesized compounds, a number of different analogs have shown interesting activity data, at least comparable to ribavirin, the unique nucleosides analogue currently approved for HCV therapy. We have discovered that the presence of bulky, apolar substituents in the glycosidic portion of the molecule results in derivatives endowed with interesting Flaviviridae inhibitory activity.