Background: Anti-citrulline antibodies (anti-CCP) are now considered an important sierologic marker for rheumatoid arthritis (RA). They have prognostic properties about erosiveness with > 75% of sensitivity and > 95% of specificity. Adult onset Still disease may have a poliarthritic RA-like presentation. Objectives: The aim of this study is to evaluate the prevalence and diagnostic value of anti-CCP in Adult Onset Still disease (AOSD) and other conditions. Methods: We have studied 123 patients: 10 AOSD (5 F, 5 M), 26 established RA (21F, 5 M), 26 Lupus erithematosus systemicus (SLE) (23 F, 3 M), 57 healthy controls (28 F, 29 M), 4 patients with circulating IgM anti-Epstain Barr virus antibodies (EBV). We have used an ELISA kit provided by Shield. The assay was performed using high purifyied sintetic peptides and anti-human IgG monoclonal antibodies linked by alcaline phosphatase. Results: Anti-CCP were present in 76% of RA patients and in 7.6% of SLE patients. Findings in AOSD, EBV and healthy controls were below of reference level. Conclusion: Our preliminar study confirm data of literature about RA. In AOSD patients we haven't found anti-CCP antibodies, analogously to results from a pediatric study about cases of juvenile idiopatic arthritis. Anti-CCP antibodies absence in AOSD with RA-like poliarticular picture may be usefull for differential diagnosis on seronegative RA.
ANTI-CITRULLINA ANTIBODIES IN ADULT ONSET STILL DISEASE. PRELIMINARY RESULTS
PADOVAN, Melissa;GOVONI, Marcello;GRALDI, Giuseppe;TROTTA, Francesco
2003
Abstract
Background: Anti-citrulline antibodies (anti-CCP) are now considered an important sierologic marker for rheumatoid arthritis (RA). They have prognostic properties about erosiveness with > 75% of sensitivity and > 95% of specificity. Adult onset Still disease may have a poliarthritic RA-like presentation. Objectives: The aim of this study is to evaluate the prevalence and diagnostic value of anti-CCP in Adult Onset Still disease (AOSD) and other conditions. Methods: We have studied 123 patients: 10 AOSD (5 F, 5 M), 26 established RA (21F, 5 M), 26 Lupus erithematosus systemicus (SLE) (23 F, 3 M), 57 healthy controls (28 F, 29 M), 4 patients with circulating IgM anti-Epstain Barr virus antibodies (EBV). We have used an ELISA kit provided by Shield. The assay was performed using high purifyied sintetic peptides and anti-human IgG monoclonal antibodies linked by alcaline phosphatase. Results: Anti-CCP were present in 76% of RA patients and in 7.6% of SLE patients. Findings in AOSD, EBV and healthy controls were below of reference level. Conclusion: Our preliminar study confirm data of literature about RA. In AOSD patients we haven't found anti-CCP antibodies, analogously to results from a pediatric study about cases of juvenile idiopatic arthritis. Anti-CCP antibodies absence in AOSD with RA-like poliarticular picture may be usefull for differential diagnosis on seronegative RA.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
