The interaction of mitochondria with the endoplasmic reticulum (ER) Ca2+ store plays a key role in allowing these organelles to rapidly and effectively respond to cellular Ca2+ signals. In this contribution, we will briefly discuss: (i) old and new concepts of mitochondrial Ca2+ homeostasis; (ii) the relationship between mitochondrial 3D structure and Ca2+ homeostasis; (iii) the modulation by cytoplasmic signalling pathways; and (iv) new data suggesting that mitochondria and ER Ca2+ channels are assembled in a macromolecular complex in which the inositol-1,4,5-trisphosphate receptor directly stimulates the mitochondrial Ca2+ uptake machinery.

Endoplasmic reticulum/mitochondria calcium cross-talk.

ROMAGNOLI, Anna;AGUIARI, Paola;DE STEFANI, Diego;LEO, Sara;MARCHI, Saverio;RIMESSI, Alessandro;ZECCHINI, Erika;PINTON, Paolo;
2007

Abstract

The interaction of mitochondria with the endoplasmic reticulum (ER) Ca2+ store plays a key role in allowing these organelles to rapidly and effectively respond to cellular Ca2+ signals. In this contribution, we will briefly discuss: (i) old and new concepts of mitochondrial Ca2+ homeostasis; (ii) the relationship between mitochondrial 3D structure and Ca2+ homeostasis; (iii) the modulation by cytoplasmic signalling pathways; and (iv) new data suggesting that mitochondria and ER Ca2+ channels are assembled in a macromolecular complex in which the inositol-1,4,5-trisphosphate receptor directly stimulates the mitochondrial Ca2+ uptake machinery.
2007
Romagnoli, Anna; Aguiari, Paola; DE STEFANI, Diego; Leo, Sara; Marchi, Saverio; Rimessi, Alessandro; Zecchini, Erika; Pinton, Paolo; Rizzuto, R....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/518800
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