The nociceptin (NC)/orphanin FQ analog, [Arg(14), Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP4). In this study, we evaluated the pharmacological profile of [Arg(14), Lys(15)]NC in vitro on the native OP4 receptors expressed in isolated tissues and in vivo in the locomotor activity and the tail-withdrawal assays in mice.
[Arg(14), Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies
RIZZI, Daniela;RIZZI, Anna;BIGONI, Raffaella;CAMARDA, Valeria;MARZOLA, Giuliano;GUERRINI, Remo;DE RISI, Carmela;REGOLI, Domenico;CALO', Girolamo
2002
Abstract
The nociceptin (NC)/orphanin FQ analog, [Arg(14), Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP4). In this study, we evaluated the pharmacological profile of [Arg(14), Lys(15)]NC in vitro on the native OP4 receptors expressed in isolated tissues and in vivo in the locomotor activity and the tail-withdrawal assays in mice.File in questo prodotto:
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