A simple entry to chiral non-racemic 2- piperazinones bearing variable substituents at the C-3 position of the heterocyclic nucleus has been developed using natural amino acids methyl esters and nitroethylene as starting materials. This methodology appears very suitable for the synthesis of a large number of piperazinone-based peptidomimetic molecules.
A simple entry to chiral non-racemic 2-piperazinone derivatives
POLLINI, Gian Piero;BARICORDI, Nikla;BENETTI, Simonetta;DE RISI, Carmela;ZANIRATO, Vinicio
2005
Abstract
A simple entry to chiral non-racemic 2- piperazinones bearing variable substituents at the C-3 position of the heterocyclic nucleus has been developed using natural amino acids methyl esters and nitroethylene as starting materials. This methodology appears very suitable for the synthesis of a large number of piperazinone-based peptidomimetic molecules.File in questo prodotto:
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