A simple entry to chiral non-racemic 2- piperazinones bearing variable substituents at the C-3 position of the heterocyclic nucleus has been developed using natural amino acids methyl esters and nitroethylene as starting materials. This methodology appears very suitable for the synthesis of a large number of piperazinone-based peptidomimetic molecules.

A simple entry to chiral non-racemic 2-piperazinone derivatives

POLLINI, Gian Piero;BARICORDI, Nikla;BENETTI, Simonetta;DE RISI, Carmela;ZANIRATO, Vinicio
2005

Abstract

A simple entry to chiral non-racemic 2- piperazinones bearing variable substituents at the C-3 position of the heterocyclic nucleus has been developed using natural amino acids methyl esters and nitroethylene as starting materials. This methodology appears very suitable for the synthesis of a large number of piperazinone-based peptidomimetic molecules.
2005
Pollini, Gian Piero; Baricordi, Nikla; Benetti, Simonetta; DE RISI, Carmela; Zanirato, Vinicio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/516736
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