A simple entry to chiral non-racemic 2- piperazinones bearing variable substituents at the C-3 position of the heterocyclic nucleus has been developed using natural amino acids methyl esters and nitroethylene as starting materials. This methodology appears very suitable for the synthesis of a large number of piperazinone-based peptidomimetic molecules.
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Data di pubblicazione: | 2005 | |
Titolo: | A simple entry to chiral non-racemic 2-piperazinone derivatives | |
Autori: | POLLINI G.P.; BARICORDI N.; BENETTI S.; DE RISI C.; ZANIRATO V. | |
Rivista: | TETRAHEDRON LETTERS | |
Parole Chiave: | Peptidomimetics; piperazinones; Michael reaction; lactamization reaction. | |
Abstract: | A simple entry to chiral non-racemic 2- piperazinones bearing variable substituents at the C-3 position of the heterocyclic nucleus has been developed using natural amino acids methyl esters and nitroethylene as starting materials. This methodology appears very suitable for the synthesis of a large number of piperazinone-based peptidomimetic molecules. | |
Digital Object Identifier (DOI): | 10.1016/j.tetlet.2005.03.163 | |
Handle: | http://hdl.handle.net/11392/516736 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |
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