An efficient method for the construction of 2-substituted-piperidin-4-one derivatives on solid support has been developed using polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form.
Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives.
BARCO, Achille;BENETTI, Simonetta;DE RISI, Carmela;MARCHETTI, Paolo;POLLINI, Gian Piero;ZANIRATO, Vinicio
1998
Abstract
An efficient method for the construction of 2-substituted-piperidin-4-one derivatives on solid support has been developed using polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form.File in questo prodotto:
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