Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives.

An efficient method for the construction of 2-substituted-piperidin-4-one derivatives on solid support has been developed using polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form.

Data di pubblicazione: 1998
Titolo: Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives.
Autori: BARCO A.; BENETTI S.; DE RISI C.; MARCHETTI P.; POLLINI G.P.; ZANIRATO V.
Rivista: TETRAHEDRON LETTERS
Parole Chiave: Solid-phase synthesis; Michael reactions; piperidinones
Abstract: An efficient method for the construction of 2-substituted-piperidin-4-one derivatives on solid support has been developed using polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form.
Handle: http://hdl.handle.net/11392/516380
Appare nelle tipologie:03.1 Articolo su rivista

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http://hdl.handle.net/11392/516380
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