AIM. In previous investigations transforming sequences of the DNA tumor virus, named simian virus 40 (SV40), have been found in human brain tumors, thereby suggesting a role for SV40 in human tumorigenesis. A recent study reported the case of a meningioma in a SV40-exposed scientist. The aim of this study was to investigate the presence of specific SV40 sequences in a laboratory investigator, professionally exposed since 1998 to the oncogenic SV40, who developed a glioblastoma multiforme. METHODS. DNA from tumor and blood specimens was analyzed by PCR and filter hybridization. RESULTS. Tumor and blood samples from the patient tested negative for SV40 sequences. CONCLUSION. Our data do not support in this clinical case the link between the SV40 exposure and the brain tumor.
GLIOBLASTOMA IN A PATIENT WITH PROFESSIONAL EXPOSURE TO THE ONCOGENIC POLYOMAVIRUS SV40.
MARTINI, Fernanda;BALATTI, Veronica;TOGNON, Mauro
2007
Abstract
AIM. In previous investigations transforming sequences of the DNA tumor virus, named simian virus 40 (SV40), have been found in human brain tumors, thereby suggesting a role for SV40 in human tumorigenesis. A recent study reported the case of a meningioma in a SV40-exposed scientist. The aim of this study was to investigate the presence of specific SV40 sequences in a laboratory investigator, professionally exposed since 1998 to the oncogenic SV40, who developed a glioblastoma multiforme. METHODS. DNA from tumor and blood specimens was analyzed by PCR and filter hybridization. RESULTS. Tumor and blood samples from the patient tested negative for SV40 sequences. CONCLUSION. Our data do not support in this clinical case the link between the SV40 exposure and the brain tumor.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
