A practical three-step procedure for the preparation of 2-methyl-1-cyclopentene-1-carboxylic acid is detailed. This process relies on the reaction of commercially available 2-carboethoxycyclopentanone with nitromethane in the presence of equimolecular amounts of piperidine, followed by denitration of the derived allylic nitro compound by treatment with 5% Pd/C in the presence of ammonium formate and final hydrolysis of the ester moiety

An efficient preparation of 2-methyl-1-cyclopentene-1-carboxylic acid, a versatile synthetic building block

BENETTI, Simonetta;DE RISI, Carmela;FERRONI, Francesco;POLLINI, Gian Piero
2007

Abstract

A practical three-step procedure for the preparation of 2-methyl-1-cyclopentene-1-carboxylic acid is detailed. This process relies on the reaction of commercially available 2-carboethoxycyclopentanone with nitromethane in the presence of equimolecular amounts of piperidine, followed by denitration of the derived allylic nitro compound by treatment with 5% Pd/C in the presence of ammonium formate and final hydrolysis of the ester moiety
2007
Benetti, Simonetta; DE RISI, Carmela; Ferroni, Francesco; Pollini, Gian Piero
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/471386
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