The iterative copper(I)-catalyzed cycloaddition (rt or MW) between an ethynyl alpha-C-mannoside and alkyl 6-azido-alpha-C-mannoside derivatives was suited to the (1,6)-ligation between alpha-D-mannose units through 1,4-disubstituted triazole bridges, thus resulting in the formation of linear oligomers (80-90% yield) with alternating triazole and mannose fragments up to a triazolo-pentamannose derivative
First synthesis of 1,2,3-triazolo-linked (1,6)-α-d-oligomannoses (triazolomannoses) by iterative Cu(I)-catalyzed alkyne-azide cycloaddition
MARRA, Alberto;DONDONI, Alessandro
2006
Abstract
The iterative copper(I)-catalyzed cycloaddition (rt or MW) between an ethynyl alpha-C-mannoside and alkyl 6-azido-alpha-C-mannoside derivatives was suited to the (1,6)-ligation between alpha-D-mannose units through 1,4-disubstituted triazole bridges, thus resulting in the formation of linear oligomers (80-90% yield) with alternating triazole and mannose fragments up to a triazolo-pentamannose derivativeFile in questo prodotto:
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