Phosphinic platinum complexes with 8-thiotheophylline derivatives: Synthesis, characterization, and antiproliferative activity

Bergamini, P.; Bertolasi, V.; Marvelli, L.; Canella, A.; Gavioli, R.; Mantovani, N.; Manas, S.; Romerosa, A.

doi:10.1021/ic062133c

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The platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)(2)(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)(2)], cis-[PtCl2(PTA)(2)], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated.

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/470085

Titolo:	Phosphinic platinum complexes with 8-thiotheophylline derivatives: Synthesis, characterization, and antiproliferative activity
Autori interni:	BERGAMINI, Paola BERTOLASI, Valerio MARVELLI, Lorenza CANELLA, Alessandro GAVIOLI, Riccardo MANTOVANI, Nicoletta
Data di pubblicazione:	2007
Rivista:	INORGANIC CHEMISTRY
Abstract:	The platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)(2)(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)(2)], cis-[PtCl2(PTA)(2)], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated.
Handle:	http://hdl.handle.net/11392/470085
Appare nelle tipologie:	03.1 Articolo su rivista

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