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EnglishThe platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)(2)(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)(2)], cis-[PtCl2(PTA)(2)], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated.
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| Data di pubblicazione: | 2007 | |
| Titolo: | Phosphinic platinum complexes with 8-thiotheophylline derivatives: Synthesis, characterization, and antiproliferative activity | |
| Autori: | BERGAMINI P.;BERTOLASI V.; MARVELLI L.; CANELLA A.; GAVIOLI R.; MANTOVANI N.; MANAS S.; ROMEROSA A. | |
| Rivista: | INORGANIC CHEMISTRY | |
| Parole Chiave: | CRYSTAL-STRUCTURES; ANTICANCER DRUGS; Platinum ligands; 1; 3; 5-TRIAZA-7-PHOSPHAADAMANTANE; CYTOTOXICITY; phosphinic platinum complexes; thiotheophylline derivatives | |
| Abstract: | The platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)(2)(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)(2)], cis-[PtCl2(PTA)(2)], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated. | |
| Digital Object Identifier (DOI): | 10.1021/ic062133c | |
| Handle: | http://hdl.handle.net/11392/470085 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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