The use of capsaicin, the pungent ingredient of red peppers, has led to the recognition that a particular subset of primary afferent neurons, which synthesize and release neuropeptides (tachykinins and CGRP) from both central and peripheral endings, innervates the mammalian urinary bladder. These neurons play a dual sensory and 'efferent' function. The former involves a modulatory influence on micturition reflex and mediation of pain arising form the bladder. The latter function, produced through local peripheral release of sensory neuropeptides, involves smooth muscle contraction and inflammation. Various chemicals normally present in the urine or generated during cystitis are adequate stimuli for exciting bladder afferents. Therefore an important role of capsaicin-sensitive primary afferents in mediating bladder pain and neurogenic inflammation in humans is speculated.
The role of capsaicin-sensitive afferents in the genesis of vesical pain and inflammation.
ABELLI, Luigi;
1993
Abstract
The use of capsaicin, the pungent ingredient of red peppers, has led to the recognition that a particular subset of primary afferent neurons, which synthesize and release neuropeptides (tachykinins and CGRP) from both central and peripheral endings, innervates the mammalian urinary bladder. These neurons play a dual sensory and 'efferent' function. The former involves a modulatory influence on micturition reflex and mediation of pain arising form the bladder. The latter function, produced through local peripheral release of sensory neuropeptides, involves smooth muscle contraction and inflammation. Various chemicals normally present in the urine or generated during cystitis are adequate stimuli for exciting bladder afferents. Therefore an important role of capsaicin-sensitive primary afferents in mediating bladder pain and neurogenic inflammation in humans is speculated.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
