Benzyl 2-azido-2-deoxy-β-d-galactopyranoside was converted into benzyl 2-azido-4,6-O-benzyl-2-deoxy-β-d-galactopyranoside via benzylidenation, p-methoxybenzylation, acid hydrolysis, benzylation, and selective oxidation. Condensation of 1,2,3,4,6-penta-O-acetyl-β-d-galactopyranose with benzyl 2-azido-4,6-di-O-benzyl-2-deoxy- β-d-galactopyranoside in the presence of trimethylsilyl triflate gave crystalline benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-d-gal actopyranosyl)-β-d-galactopyranoside (76%), which was converted into benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-3-O-(2,6-di-O-benzyl-β-d-galactopyr anosyl)-β-d-galactopyranoside and condensed with 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-d-galactopyranosyl bromide in the presence of silver silicate on alumina and molecular sieve 4 Å to give 61% of benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-d-galactopyranosyl)- (1→4)-O-(2,6-di-O-benzyl-β-d-galactopyranosyl)-(1→3)-2- azido-4,6-di-O-benzyl-2-deoxy-β-d-galactopyranoside. Reduction with sodium borohydride followed by N-acetylation, O-deacetylation, and catalytic hydrogenolysis then gave O-(2-acetamido-2-deoxy-β-d-galactopyranosyl)-(1→4)-O-β-d- galactopyranosyl-(1→3)-2-acetamido-2-deoxy-d-galactopyranose, the desialylated human Cad-antigenic determinant. © 1986.
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Data di pubblicazione: | 1986 | |
Titolo: | CHEMICAL SYNTHESIS OF THE DESIALYLATED HUMAN CAD-ANTIGENIC DETERMINANT | |
Autori: | CATELANI G; A. MARRA; PAQUET F; SINAY P | |
Rivista: | CARBOHYDRATE RESEARCH | |
Abstract: | Benzyl 2-azido-2-deoxy-β-d-galactopyranoside was converted into benzyl 2-azido-4,6-O-benzyl-2-deoxy-β-d-galactopyranoside via benzylidenation, p-methoxybenzylation, acid hydrolysis, benzylation, and selective oxidation. Condensation of 1,2,3,4,6-penta-O-acetyl-β-d-galactopyranose with benzyl 2-azido-4,6-di-O-benzyl-2-deoxy- β-d-galactopyranoside in the presence of trimethylsilyl triflate gave crystalline benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-d-gal actopyranosyl)-β-d-galactopyranoside (76%), which was converted into benzyl 2-azido-4,6-di-O-benzyl-2-deoxy-3-O-(2,6-di-O-benzyl-β-d-galactopyr anosyl)-β-d-galactopyranoside and condensed with 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-d-galactopyranosyl bromide in the presence of silver silicate on alumina and molecular sieve 4 Å to give 61% of benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-d-galactopyranosyl)- (1→4)-O-(2,6-di-O-benzyl-β-d-galactopyranosyl)-(1→3)-2- azido-4,6-di-O-benzyl-2-deoxy-β-d-galactopyranoside. Reduction with sodium borohydride followed by N-acetylation, O-deacetylation, and catalytic hydrogenolysis then gave O-(2-acetamido-2-deoxy-β-d-galactopyranosyl)-(1→4)-O-β-d- galactopyranosyl-(1→3)-2-acetamido-2-deoxy-d-galactopyranose, the desialylated human Cad-antigenic determinant. © 1986. | |
Digital Object Identifier (DOI): | 10.1016/S0008-6215(00)90139-3 | |
Handle: | http://hdl.handle.net/11392/462260 | |
Appare nelle tipologie: | 03.1 Articolo su rivista |