This study aimed to characterize alpha-adrenergic receptors in catfish hepatocytes in which catecholamine-induced calcium transients have bee observed. Alpha-adrenergic binding sites werw studied in purified liver membranes using specific alpha1-receptor antagonis 3H-prazosin. The relative potency of selective adrenoceptor ligands points to the presence in catfish liver of alpha-adrenergic receptors in addition to the beta-adrenergic receptor population previously characterized. Moreover, the binding data have been correlated to the glucose release from isolated hepatocytes suspended and perifused in a BioGel column, suggesting the involvement of alpha-adrenergic receptors in the glycogenolytic respnse to catecholamines in catfish hepatocytes.

Identification of alpha-adrenergic receptors in catfish liver and their involvement in glucose release

FABBRI E.
Primo
;
PUVIANI A. C.
Secondo
;
OTTOLENGHI C.;CAPUZZO, Antonio
Ultimo
1994

Abstract

This study aimed to characterize alpha-adrenergic receptors in catfish hepatocytes in which catecholamine-induced calcium transients have bee observed. Alpha-adrenergic binding sites werw studied in purified liver membranes using specific alpha1-receptor antagonis 3H-prazosin. The relative potency of selective adrenoceptor ligands points to the presence in catfish liver of alpha-adrenergic receptors in addition to the beta-adrenergic receptor population previously characterized. Moreover, the binding data have been correlated to the glucose release from isolated hepatocytes suspended and perifused in a BioGel column, suggesting the involvement of alpha-adrenergic receptors in the glycogenolytic respnse to catecholamines in catfish hepatocytes.
1994
Fabbri, E.; Puviani, A. C.; Ottolenghi, C.; Capuzzo, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460985
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