This study aimed to characterize alpha-adrenergic receptors in catfish hepatocytes in which catecholamine-induced calcium transients have bee observed. Alpha-adrenergic binding sites werw studied in purified liver membranes using specific alpha1-receptor antagonis 3H-prazosin. The relative potency of selective adrenoceptor ligands points to the presence in catfish liver of alpha-adrenergic receptors in addition to the beta-adrenergic receptor population previously characterized. Moreover, the binding data have been correlated to the glucose release from isolated hepatocytes suspended and perifused in a BioGel column, suggesting the involvement of alpha-adrenergic receptors in the glycogenolytic respnse to catecholamines in catfish hepatocytes.
Identification of alpha-adrenergic receptors in catfish liver and their involvement in glucose release
FABBRI E.Primo
;PUVIANI A. C.Secondo
;OTTOLENGHI C.;CAPUZZO, AntonioUltimo
1994
Abstract
This study aimed to characterize alpha-adrenergic receptors in catfish hepatocytes in which catecholamine-induced calcium transients have bee observed. Alpha-adrenergic binding sites werw studied in purified liver membranes using specific alpha1-receptor antagonis 3H-prazosin. The relative potency of selective adrenoceptor ligands points to the presence in catfish liver of alpha-adrenergic receptors in addition to the beta-adrenergic receptor population previously characterized. Moreover, the binding data have been correlated to the glucose release from isolated hepatocytes suspended and perifused in a BioGel column, suggesting the involvement of alpha-adrenergic receptors in the glycogenolytic respnse to catecholamines in catfish hepatocytes.File | Dimensione | Formato | |
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