On phenyl and cyano phases log k' values were determined, for a series of benzodiazepines. The log k' values linearly extrapolated at 100% water were highly significantly correlated to log P values. A comparison with the most commonly used octadecyl phase demonstrates that phenyl is the best phase for log P prediction, cyano the most sensitive to the presence of particular moieties in the solute molecule, whereas octadecyl allows to obtain the most sensible measure of solute lipophylicity. © 1987, Taylor & Francis Group, LLC. All rights reserved.
Octadecyl, phenyl and cyano phases comparison for the RP-HPLC prediction of octanol-water partition coefficient
PIETROGRANDE, Maria Chiara;DONDI, Francesco;BLO, Gabriella;BOREA, Pier Andrea;BIGHI, Corrado
1987
Abstract
On phenyl and cyano phases log k' values were determined, for a series of benzodiazepines. The log k' values linearly extrapolated at 100% water were highly significantly correlated to log P values. A comparison with the most commonly used octadecyl phase demonstrates that phenyl is the best phase for log P prediction, cyano the most sensitive to the presence of particular moieties in the solute molecule, whereas octadecyl allows to obtain the most sensible measure of solute lipophylicity. © 1987, Taylor & Francis Group, LLC. All rights reserved.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
