A quantitative study of the relationship between structure and receptor binding affinity of a series of 16β-carbolines showed the influence of lipophilic character and hydrogen bonding capability of substituents in position 3. Some data taken from the literature enabled us to add some evidence about the influence ofplanarity of ring C and bulky substituents in position 1 in determining the receptor binding affinity. © 1988.
The influence of lipophilic character on receptor binding affinity of a series of beta-carbolines
BOREA, Pier Andrea;PIETROGRANDE, Maria Chiara;BIAGI, Federico
1988
Abstract
A quantitative study of the relationship between structure and receptor binding affinity of a series of 16β-carbolines showed the influence of lipophilic character and hydrogen bonding capability of substituents in position 3. Some data taken from the literature enabled us to add some evidence about the influence ofplanarity of ring C and bulky substituents in position 1 in determining the receptor binding affinity. © 1988.File in questo prodotto:
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