A convergent one-pot construction of functinalized pyrrolidine ring sistems has been developed.The method is based on a tandem Michael reaction initiated by an intramolecular conjugate addition of a nitrogen nucleophile to an electophilic olefin followed by trapping of the generated enolate by a bult-in unsaturated acceptor.

A new approach to kainoids through tandem Michael reaction methodology: application to the enantioselective synthesis of (+) and (-)-a-Allokainic acid and to the formal synthesis of (-)-a-Kainic acid. A. Barco, S. Benetti, A.Casolari, G.P. Pollini, G. Spalluto, V. Zanirato ,

BARCO, Achille;BENETTI, Simonetta;CASOLARI, Alberto;POLLINI, Gian Piero;ZANIRATO, Vinicio
1992

Abstract

A convergent one-pot construction of functinalized pyrrolidine ring sistems has been developed.The method is based on a tandem Michael reaction initiated by an intramolecular conjugate addition of a nitrogen nucleophile to an electophilic olefin followed by trapping of the generated enolate by a bult-in unsaturated acceptor.
1992
Barco, Achille; Benetti, Simonetta; Spalluto, G.; Casolari, Alberto; Pollini, Gian Piero; Zanirato, Vinicio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460295
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