A new approach to kainoids through tandem Michael reaction methodology: application to the enantioselective synthesis of (+) and (-)-a-Allokainic acid and to the formal synthesis of (-)-a-Kainic acid. A. Barco, S. Benetti, A.Casolari, G.P. Pollini, G. Spalluto, V. Zanirato ,

A convergent one-pot construction of functinalized pyrrolidine ring sistems has been developed.The method is based on a tandem Michael reaction initiated by an intramolecular conjugate addition of a nitrogen nucleophile to an electophilic olefin followed by trapping of the generated enolate by a bult-in unsaturated acceptor.

Data di pubblicazione: 1992
Titolo: A new approach to kainoids through tandem Michael reaction methodology: application to the enantioselective synthesis of (+) and (-)-a-Allokainic acid and to the formal synthesis of (-)-a-Kainic acid. A. Barco, S. Benetti, A.Casolari, G.P. Pollini, G. Spalluto, V. Zanirato ,
Autori: A . BARCO; S. BENETTI; G . SPALLUTO; A . CASOLARI; G . P. POLLINI; V . ZANIRATO
Rivista: JOURNAL OF ORGANIC CHEMISTRY
Abstract: A convergent one-pot construction of functinalized pyrrolidine ring sistems has been developed.The method is based on a tandem Michael reaction initiated by an intramolecular conjugate addition of a nitrogen nucleophile to an electophilic olefin followed by trapping of the generated enolate by a bult-in unsaturated acceptor.
Digital Object Identifier (DOI): 10.1021/jo00049a040
Handle: http://hdl.handle.net/11392/460295
Appare nelle tipologie:03.1 Articolo su rivista

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