Skin lesions (wounds, scabs, areas of alopecia) are observed mainly in the head of most rats treated as newborns with capsaicin. No major differences were recorded between capsaicin-or vehicle-treated animals in spontaneous or novelty-induced grooming. Both SP-LI and TK-LI in various skin areas were significantly reduced by systemic capsaicin pretreatment. Fur regrowth was reduced and skin ulcers increased in caspaicin-pretreated rats. All these findings indicate that capsaicin-sensitve nerves play a trophic role in the rat skin. The restricted localization of skin lesions apparently results from 'normal' injurious factors (such grooming) on a distrophic skin.
Cutaneous lesions in capsaicin-pretreated rats: a trophic role of capsaicin-sensitive afferents?
ABELLI, Luigi;
1987
Abstract
Skin lesions (wounds, scabs, areas of alopecia) are observed mainly in the head of most rats treated as newborns with capsaicin. No major differences were recorded between capsaicin-or vehicle-treated animals in spontaneous or novelty-induced grooming. Both SP-LI and TK-LI in various skin areas were significantly reduced by systemic capsaicin pretreatment. Fur regrowth was reduced and skin ulcers increased in caspaicin-pretreated rats. All these findings indicate that capsaicin-sensitve nerves play a trophic role in the rat skin. The restricted localization of skin lesions apparently results from 'normal' injurious factors (such grooming) on a distrophic skin.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
