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|Titolo:||Neurokinin receptors in the rat lower urinary tract.|
|Autori interni:||ABELLI, Luigi|
|Data di pubblicazione:||1988|
|Rivista:||JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS|
|Abstract:||The effects of neurokinins (NKs), tachykinins and some NKrelated peptides (selective agonists for the NK-1 , NK-2 or NK-3 receptors) have been investigated in the various sections of the rat lower urinary tract. In the isolated bladder, all peptides were substantially equipotent with the exception of senktide, an NK-3 agonist, which was distinctly less potent than the other compounds. Similar results were obtained in the isolated urethra. In these tissues, the maximal response to NK-1 agonists was distinctly less intense than that to the other peptides. In the bladder, exposure to phenoxybenzamine (30 ıM for 90 mm) reduced the response to NK-A but not that to substance P, KCI or field stimulation. In the isolated ureter, peptides active at both the NK-2 and the NK-3 sites [including senktide and [MePhe7]- NKB(4-1 0)] activated, at nanomolar concentrations a series of rhythmic contractions, whereas peptides active at the NK-1 site, were active only at micromolar concentrations. These findings provide further evidence that multiple NK receptors are present in the rat lower urinary tract. In the bladder, NK-2 and NK-1 sites mediate the direct response to NKs, in accordance with binding and autoradiographic data. In the ureter, both NK-2 and NK-3 sites may activate the direct contractile response to these substances.|
|Appare nelle tipologie:||03.1 Articolo su rivista|
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