Intravesical instillation of xylene through an implanted catheter produced in rats behavioural effects suggestive of pain. These were prevented by systemic capsaicin desensitization of rats as adults or newborns (that produced almost complete depletion of SP-, NKA- and CGRP-LI in the urinary bladder), as well as by extrinsic bladder denervation. These findings propose the involvement of neuropeptides-containing, capsaicin-sensitive seonsory nerves of the rat bladder in chemogenic visceral pain.
The contribution of capsaicin-sensitive sensory nerves to xylene-induced visceral pain in conscious, freely moving rats.
ABELLI, Luigi;
1988
Abstract
Intravesical instillation of xylene through an implanted catheter produced in rats behavioural effects suggestive of pain. These were prevented by systemic capsaicin desensitization of rats as adults or newborns (that produced almost complete depletion of SP-, NKA- and CGRP-LI in the urinary bladder), as well as by extrinsic bladder denervation. These findings propose the involvement of neuropeptides-containing, capsaicin-sensitive seonsory nerves of the rat bladder in chemogenic visceral pain.File in questo prodotto:
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