The ability of a selective agonist for NK-2 tackhykinin receptors to stimulate micturition in anaesthetised rats and guinea-pigs was investigated. In both species, the intravesical instillation of the peptide at uM concentrations reduced bladder capacity and residual volume, indicating a facilitatory effect on reflex micturition, whereas no plasma extravasation was produced as determined by Evans Blue leakage. In experiments on the isolated rat or guinea-pig bladder strips, the peptide induced powerful contractions. In a in vitro model of the guinea-pig whole bladder the intravesical instillation of the agonist facilitated the occurrence of rhythmic contractile activity. The selective NK-2 receptor agonist is likely able to cross the urothelium and stimulate smooth muscle contraction.
Facilitation of reflex micturition by intravesical administration of [bAla8]-neurokinin A (4-10), a selective NK-2 tachykinin receptor agonist.
ABELLI, Luigi;
1991
Abstract
The ability of a selective agonist for NK-2 tackhykinin receptors to stimulate micturition in anaesthetised rats and guinea-pigs was investigated. In both species, the intravesical instillation of the peptide at uM concentrations reduced bladder capacity and residual volume, indicating a facilitatory effect on reflex micturition, whereas no plasma extravasation was produced as determined by Evans Blue leakage. In experiments on the isolated rat or guinea-pig bladder strips, the peptide induced powerful contractions. In a in vitro model of the guinea-pig whole bladder the intravesical instillation of the agonist facilitated the occurrence of rhythmic contractile activity. The selective NK-2 receptor agonist is likely able to cross the urothelium and stimulate smooth muscle contraction.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.