Ultrasound assessment of temporomandibular disorders: comparative analysis between inflammatory and degenerative patterns in rheumatic and non-rheumatic patients

Background: Temporomandibular disorders (TMDs) encompass a range of conditions affecting the temporomandibular joint (TMJ), with causes that may be inflammatory or degenerative. Differentiating these mechanisms is essential for targeted treatment, especially in patients with underlying rheumatic diseases. Objective: This prospective, cross-sectional study assessed the utility of ultrasound (US) in distinguishing inflammatory from degenerative TMJ changes across different patient populations. Methods: From 2018 to February 2025, 272 patients with TMD symptoms underwent standardized TMJ US. They were grouped into those with inflammatory rheumatic diseases (n = 202), primary fibromyalgia (n = 33), and individuals without rheumatologic conditions (n = 37). A control group of 40 healthy subjects was also included. US findings assessed included joint effusion, synovial hypertrophy, power Doppler (PD) signal, erosions, condylar irregularities, and disc dislocation. Clinical symptoms and signs were also recorded. Results: Inflammatory findings (synovitis, effusion, PD signal) were significantly more frequent in the rheumatic group (p < 0.05). Physical exam alone could not reliably distinguish inflammatory from mechanical causes (66.4% vs 33.6%, p = 0.634). Degenerative changes were common in all groups, possibly reflecting chronic mechanical stress. PD signal appeared in some fibromyalgia cases, suggesting possible secondary inflammation. Articular erosions were the only US feature significantly correlated with symptoms. Conclusion: Ultrasound is a sensitive, non-invasive tool for assessing TMJ involvement, particularly in distinguishing inflammatory from mechanical patterns. Its integration into clinical evaluation improves diagnostic accuracy and informs more personalized management. (Table presented.)