Editorial: Immune insights into orthopedic infections: mechanisms, biomarkers, and prevention

Orthopedic infections arise from complex interactions between invading pathogens, the immune system, and the bone–implant interface, resulting in persistent inflammation, biofilm formation, and impaired tissue regeneration. As surgical procedures and implant use continue to rise worldwide, the burden of these infections remains substantial, highlighting the need for more effective diagnostic, preventive, and therapeutic strategies. Their clinical impact extends far beyond the acute infectious episode, influencing tissue healing, implant stability, long-term function, and overall quality of life.