Historical Background Extracellular purine and pyrimidine nucleotides act as signaling molecules through the activation of P2X ion channels and P2Y G protein-coupled receptors (GPCRs) (Abbracchio et al. 2006). Among the eight members of the P2Y receptor family, four respond to extracellular uracil nucleotides: P2Y2, P2Y4, P2Y6, and P2Y14 receptors. None of the P2X ion channels are substantially activated by uracil nucleotides. P2Y2, P2Y4, and P2Y6 receptors belong to the P2Y1-like subgroup of Gq-coupled receptors, and the P2Y14 receptor belongs to the P2Y12-like subgroup that couples to G protein αi to inhibit adenylyl cyclase. The P2Y14 receptor is distributed in various tissues, that is, placenta, adipose, stomach, intestine, spleen, thymus, lung, heart, mast cells, and discrete brain regions (Freeman et al. 2001; Harden et al. 2010). It is activated by uridine-5′-diphosphoglucose (UDPG, 1, Fig. 1), other endogenous UDP-sugars, and uridine-5′-diphosphate...
P2Y14 Receptor
Ciancetta APenultimo
;
2016
Abstract
Historical Background Extracellular purine and pyrimidine nucleotides act as signaling molecules through the activation of P2X ion channels and P2Y G protein-coupled receptors (GPCRs) (Abbracchio et al. 2006). Among the eight members of the P2Y receptor family, four respond to extracellular uracil nucleotides: P2Y2, P2Y4, P2Y6, and P2Y14 receptors. None of the P2X ion channels are substantially activated by uracil nucleotides. P2Y2, P2Y4, and P2Y6 receptors belong to the P2Y1-like subgroup of Gq-coupled receptors, and the P2Y14 receptor belongs to the P2Y12-like subgroup that couples to G protein αi to inhibit adenylyl cyclase. The P2Y14 receptor is distributed in various tissues, that is, placenta, adipose, stomach, intestine, spleen, thymus, lung, heart, mast cells, and discrete brain regions (Freeman et al. 2001; Harden et al. 2010). It is activated by uridine-5′-diphosphoglucose (UDPG, 1, Fig. 1), other endogenous UDP-sugars, and uridine-5′-diphosphate...I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
