This project will focus on the molecular mechanisms involved in RAD21-mutated CIPO leading to enteric neurons alterations thereby affecting gut motility. We will use a genetically constructed Rad21A626T mouse model to address gut dysfunction and molecular abnormalities, better understand neurogenic CIPO and identify potentially druggable pathways to compensate the deranged mechanisms. The foreseen steps in the TDP outline will start from 1 to 3 of the Basic Research Plan.
DONOR: studio di un modello murino di pseudo-ostruzione intestinale cronica dovuta ai meccanismi mlecolari dipendenti da RAD21
roberto de giorgio
2023
Abstract
This project will focus on the molecular mechanisms involved in RAD21-mutated CIPO leading to enteric neurons alterations thereby affecting gut motility. We will use a genetically constructed Rad21A626T mouse model to address gut dysfunction and molecular abnormalities, better understand neurogenic CIPO and identify potentially druggable pathways to compensate the deranged mechanisms. The foreseen steps in the TDP outline will start from 1 to 3 of the Basic Research Plan.File in questo prodotto:
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DONOR_ Studio di un moDello murino di pseudo-Ostruzione iNtestinale crOnica dovuta ai meccanismi molecolari dipendenti da RAD21.pdf
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