Fluid redox biomarkers in neurological disease

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

Redox imbalance is a common physiopathological feature in neurological disease, especially those with a relevant neurodegenerative component. The consequent damage to biomolecules leads to the generation of various relatively stable by-products, which can serve as biomarkers of oxidative stress. A wealth of epidemiological and clinical evidence has found an association between alteration of these fluid biomarkers and the occurrence of neurological diseases, in particular Alzheimer's disease (AD), vascular dementia (VD), and Parkinson's disease (PD). However, also conflicting results are reported. Herein, we systematically review the published data on this topic highlighting the methodological issues that hinder the definitive appreciation of the use of redox biomarkers in the diagnosis and prediction of the above-mentioned disorders.